Research Paper On Alzheimers


This section highlights some of the groundbreaking research and guidance documents published or presented by Alzheimer's Association professional staff, funded researchers or volunteer science advisors.

 Review of Scientific Evidence Addressing Prevalence, Documented Needs, and Interdisciplinary Research:  Persons in Early Stage Alzheimer’s Dementia (141 pages)
Prepared for the Alzheimer's Association Early Stage Advisory Group by Sandy Burgener, Linda Buettner and collegues
Comprehensive literature review of the scientific literature non-pharmacological interventions for people in Early Stage Alzheimer's disease and other forms of dementia.

 Research Consent for Cognitively Impaired Adults - Recommendations for Institutional Review Boards and Investigators: Consensus Recommendations (5 pages)
Prepared by the Alzheimer's Association  
This paper appeared in Alzheimer's Disease and Associated Disorders July-Sept. 2004. The document contains recommendations that Institutional Review Boards and investigators can use to operationalize the informed consent process for individuals with cognitive impairment.

 Interventions to Improve Quality of Care: The Kaiser Permanente-Alzheimer’s Association Dementia Care Project (8 pages)
Prepared by Alzheimer’s Association Los Angeles chapter staff and Kaiser colleagues 
This paper from the August 2004 American Journal of Managed Care describes an Alzheimer’s Association-Kaiser Permanente joint initiative to improve the quality of dementia care in the Kaiser Permanente Los Angeles area managed care network. The project developed dementia diagnosis and management guidelines for Kaiser physicians, proactively encouraged guideline use, and provided care management support through social workers. Individuals with dementia, their caregivers and Kaiser health care professionals all expressed higher rates of satisfaction with care quality provided by the project.

 Dementia and Serious Coexisting Medical Conditions: A Double Whammy (19 pages)
Prepared by Katie Maslow, M.S.W., Alzheimer’s Association associate director, quality care 
This paper from Nursing Clinics of North America 2004, vol. 39, discusses the widespread occurrence of other serious medical conditions in individuals with dementia; explores how coexisting conditions may worsen cognitive symptoms and create treatment challenges for care professionals and family caregivers; and analyzes the impact of coexisting conditions on use and cost of health care.

 Alzheimer's Disease, the Alzheimer’s Association and Stem Cell Research (1 page)
Prepared by the Alzheimer’s Association
This document was prepared on June 14, 2005 to provide background information and address common questions about stem cell research and Alzheimer’s disease.

 Guidelines for the Development of Community-Based Screening Programs for Cognitive Impairment in Older People (12 pages, guidelines begin on page 6)
Prepared by the Alzheimer’s Association Work Group on Screening for Cognitive Impairment and Alzheimer’s Disease 
This paper in the June 21, 2001, issue of Alzheimer Insights, a peer-reviewed online journal, presents the recommendations of independent experts and Alzheimer’s Association senior science and public policy staff on issues and challenges related to community screening for dementia. The guidelines outline 21 questions that must be considered in the design of a community screening program. If many of these questions pose problems, the sponsoring group may wish to consider launching a community education initiative in place of a screening program.

 The Use of MRI and PET for Clinical Diagnosis of Dementia and Investigation of Cognitive Impairment: A Consensus Report   (15 pages)
Prepared by the Neuroimaging Work Group of the Alzheimer's Association
Posted June 1, 2004
This report represents the consensus of 22 independent experts assembled by the Alzheimer's Association on the current value and appropriate use of magnetic resonance imaging (MRI) and positron emission tomography (PET) in diagnosing Alzheimer's disease and related disorders, tracking disease progression, and monitoring response to experimental treatments. The report also recommends directions for future research.

 End-of-Life Care for People with Dementia in Residential Care Settings  (35 pages)
Prepared for the Alzheimer’s Association by Ladislav Volicer, M.D., Ph.D., School of Aging Studies, University of South Florida, Tampa
The Alzheimer’s Association commissioned this literature review on end-of-life care for nursing home residents with advanced dementia as part of its Campaign for Quality Residential Care. The goal is to document the current state of end-of-life care, provide an evidence base for practice and policy recommendations to improve care, and stimulate further research in this area.

University of North Carolina Institute on Aging's Online Bibliography on Alzheimer's Disease and Dementia in Diverse Populations
Comprehensive online bibliography of the social and behavioral research related to Alzheimer's disease and other forms of dementia.

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What Is Alzheimer’s Disease?

Alzheimer’s disease (AD) is an irreversible disease of the brain that affects a person’s memory, thinking, and other abilities.

How Common Is Alzheimer’s Disease?

Alzheimer’s disease is the most common form of dementia in people age 65 and over. Over 5.2 million Americans are estimated to have Alzheimer’s disease. By 2050 this number is expected to reach 11 to 16 million (Alzheimer’s Association, 2009).

How the Brain Changes With Alzheimer’s Disease

Alzheimer’s disease is a progressive disease, meaning that it gets worse and more functions are lost as more time passes. Some studies suggest that Alzheimer’s disease may begin attacking the brain long before symptoms are present. The disease first attacks the memory center of the brain, which causes people with AD to become more forgetful. As the disease progresses, the person may also begin to have other problems, such as problems with thinking and walking.

Alzheimer’s Disease Is NOT a Normal Part of Aging

Despite what some people think, getting Alzheimer’s disease is not a normal part of aging. However, it is true that people are more likely to develop AD as they grow older. There is no cure for AD, but there are multiple treatments that can slow down the progression of the disease. Researchers believe that an individual who is diagnosed with AD at age 65 may live an average of 8-10 years (Alzheimer’s Disease Research, 2009). Although an individual older than 80 may only live 3 or 4 years after being diagnosed (NIA 2010).

More About Causes and Symptoms of Alzheimer’s Disease

Causes, risk factors, and symptoms of Alzheimer’s disease are somewhat different from other forms of dementia. Follow the links below to learn more.

More About Diagnosis and Treatment of Alzheimer’s Disease

Approaches to diagnosis and treatment of Alzheimer’s disease are similar to other forms of dementia. Follow the links below to learn more.

View References

Alzheimer’s Association. Research. Available at: http://www.alz.org/join_the_cause_research_jtc.asp. Retrieved March 30, 2009.

Alzheimer’s Disease Research. Alzheimer’s Symptoms and Stages. Available at: http://www.ahaf.org/alzheimers/about/symptomsandstages.html . Retrieved March 30, 2009.

National Institute for Aging. Alzheimer’s Information. ADEAR Website. 2010. Available at: http://www.nia.nih.gov/nia.nih.gov/Templates/ADEARCommon/ADEARCommonPage.aspx?NRMODE=Published&NRNODEGUID={2D13AE9A-D6EF-4546-9F02-66D3B3CC1453}&NRORIGINALURL=%2fAlzheimers%2fAlzheimersInformation%2fGeneralInfo%2f&NRCACHEHINT=Guest#howlong. Retrieved on July 16, 2010

Resources

Alzheimer's Association Homepage

Source: Alzheimer's Association
Description: The Alzheimer's Association is one of the most popular resources for AD information online. It contains educational materials, information on support groups, community programs, current research, and many other resources for individuals with dementia and their caregivers.

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What is Alzheimer's?

Source: Alzheimer's Association
Description: This web page provides a brief introduction to Alzheimer's disease including the biological changes in the disease, a discussion of the history of this disease, and the difference between “early stages” of Alzheimer's disease and “early onset” Alzheimer's.

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Alzheimer's Disease Education and Referral Center (ADEAR)

Source: National Institute on Aging (NIA)
Description: The ADEAR Center offers education on Alzheimer's disease and dementia including current news and events, information for caregivers, links to government publications and reports, and information about participating in current clinical trials. You can sign up to be alerted by email when ADEAR have something new to offer. You can also search a database of fact sheets, textbook chapters, journal articles, brochures, teaching manuals, directories, videos and other media, bibliographies, program descriptions, monographs, newsletters, and reports related to Alzheimer's disease.

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Alzheimer Research Forum

Source: Alzheimer Research Forum
Description: This scientific website features information on research into medications used in the treatment of Alzheimer's, hereditary factors contributing to the development of Alzheimer's, and other topics. It includes information on clinical trials, news about research, recently published papers related to Alzheimer's, information on grants for doing research in this area, a list of members, researchers, and institutes and labs, and links to resources for disease management.

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